From a game design perspective the problem with the humans, androids and Alien in Alien: Isolation was that, generally speaking, they were basically the same. Now, hear me out: all three have different strengths and weaknesses; the problem arises in the way the player interacts with them.
When interacting with the Alien, confrontation isn’t really an option. Sure, you can drive it off if it finds you and you’re quick enough with the flamethrower or molotov, but this expends very limited resources and the Alien will always return. Much better to hide somewhere and wait for it to pass.
Similarly, the Working Joes are rarely worth the time and resources to put down. They hit like a truck, they’re rarely alone, and confronting them directly consumes a lot of resources and makes a lot of noise. Uniquely, if you have the space you can literally run past them, but this runs the risk of making enough noise to call the creature. Again, it’s best to sneak around and avoid them entirely.
Finally, there’s the humans. They’re not always hostile, but when they are (and they very frequently are), they tend to be very noisy and very lethal. Humans aren’t hard to put down, but the fastest and most effective ways to stop them are messy and loud. Moreover, outside of a handful of passwords to rooms or lockers that a few, specific scripted encounters provide, there’s never any benefit to engaging them. Yet again, the best course of action is stealth and avoidance.
As a result, we’re stuck with a situation where there are three distinct enemy types around the station but the best method of interacting with all of them is the same. All three enemy types in the game test the exact same skills of the player, namely patience and stealth. There is almost never any benefit to the player in intentionally engaging any of the above. It is a risk that almost never pays off.
Getting back on topic, given the above, I don’t feel like Working Joes or hostile human survivors would make for a meaningful contribution to a game of the style of A:B. Working Joes in particular are cool and I’d love to see them expanded on more in any future full A:I sequels we get, but I think the premise of A:B would benefit more from focusing on the Big Chap exclusively as the antagonistic force.