I remember when the GoI dev linked Detention, I was intrigued because I pretty much never see games (with English-language versions) that are set in Taiwan. That is probably the case for many, many real-world places. (Unfortunately, Detention turned out to be a horror game, which is very much not my thing.)
On the fantastical-premise side, though, I don’t think I have a particular yearning for a specific setting as long as it is done with great thought and care. I would love to see a very rigorously conlanged game play with language as part of the social setting, but I would have… uh… extremely high standards for that, probably. As in “I side-eye the use of conlang in GoT, please don’t bring that up” standards.
(Text games have already played with this sometimes, mostly in a more whimsical way – I loved “The Gostak”, which wasn’t so much about conlanging as it was about English grammar and morphology, and the common vocabularies of “second-wave” parser games.)