Something that is increasingly driving me away from games is spiders. I’m quite arachnophobic and there are quite a few games where I’ve reached certain points and been unable to continue. Probably the most disappointing is Bloodborne, which I dumped dozens of hours into before getting to Nightmare of Mensis and being kind of unable to proceed. I was recently tempted by Nioh before seeing some of the spider enemies there.
There have been a couple of spider heavy games which I’m OK with (mainly Diablo 3, which has not especially realistic spiders, and Path of Exile, which has spiders which don’t always trigger my arachnophobia). On the other hand there have been quite a few games where I have insta-noped (such as Torchlight 2) even though the spiders aren’t necessarily that realistic.