Zone of the Enders Dolores:i is what I think you’re looking for, OP. It’s based on Kojima’s weirdly cool mech games. Where it fits in the continuity is a little weird since it’s a direct sequel to the OVA prequel to the first game, which means the first episodes take place in between the OVA and the first game and the last ones occur between the first game and the second game.
But all of that is secondary to why it’s an awesome show. It’s about a space-trucker dad who is estranged from his adult children after his wife disappears in a mysterious accident. The long-haul flights of a space freighter give him plenty of time to drink and self-pity, but he’s shaken out of it after a mysterious package he’s tasked to move leads to his being framed as a terrorist.
The package turns out to be Dolores, an AI-driven Orbital Frame with immense destructive capabilities who calls him her uncle.
He manages to reconnect with his children and winds up flying across the solar system as a wanted man while managing to engage in some serious action (including an episode that’s basically Die Hard on Mars).
Surprisingly for something even remotely associated with Kojima, it’s occasionally a bit retrograde in its morality (although generally subversive) but hardly skeezy at all! For some reason all the mechs really do have _cock_pits which leads to some odd imagery, but apart from some outmoded Freudian ideas about child development applying to the AI there’s almost nothing to label actually problematic.
Somebody has been nice enough to put the entire dubbed show on Youtube, although I’m not sure where you’d go for the subbed version.
You can find the OVA here:
It’s more actiony and “mature” but it’s less fun than Dolores, and in my opinion pretty hokey. Still, worth watching to get the whole context.