It doesn’t necessarily need to be constructed like an escort mission! If the focus is on safely battling the supervillain (which, yes, please, god it makes me cringe to think of all the collateral damage in superhero/action movies), you can conceptualize “ensure civilians are not harmed” as a kind of hazard or obstacle. Plenty of combat-oriented games place you on a field where you must also avoid or manage environmental hazards while duking it out with an opponent, after all. Here, harm of civilians constitutes an ethical hazard in the arena, if not a physical one.
And if the focus is more directly on the protection of the civilians, that’s fine too – it still doesn’t have to be an escort. For instance, if a supervillain is marching down streets of Randotown with an army of robotic minions or whatnot, you’re not going to be escorting the civilians away individually – that would be both 1) impossible [herding people: worse than herding cats?] and 2) impractical. You’d maybe have a “contagious” AOE yell that would encourage civilians to start getting out of the way, with repeated applications increasing the efficacy and direct auditory contact being more effective than the word-of-mouth; a small handful of civilians might be too slow to make it on foot and need to be carried to a nearby shelter location; stubborn or oblivious stayers at the very end might need the push out of the way (but having had the near miss, will then come to their senses and run away on their own).