How recent is recent? (I’m also one of those weird people who thinks that originality is BS, so I’m interpreting the question more like “this hasn’t really been done in a game before” than “this hasn’t been done at all.”)
I think Hyper Light Drifter is an amazing narrative about illness and trauma set against a post-apocalyptic backdrop, expressed through a lot of little touches in its world (the character coughing up blood after every death, the heart motifs that crop up around the game), but if you don’t know about its developer’s history with heart disease that might not come across.
I think SOMA is a fantastic meditation on consciousness and humanity that leaves all of its cards on the table from the get-go, and would probably be my #1 answer to this question when all’s said and done. I think Prey also does some similar things, albeit they’re way more subliminal and only really come to the surface after its post-credits ending.
I think Life is Strange is super-derivative of detective fiction and YA (specifically boarding school) fiction, but there really aren’t any games that do what it does, and it does some really creative things with the tropes that it borrows. Similarly, Firewatch is nothing original by contemporary fiction standards (dude has personal problems, goes to the woods to find himself, stumbles upon a tragedy) but by game standards it’s pretty unique.
I think Overwatch has an extremely reductive and derivative story, but its commitment to actual optimistic futurism in an almost Disney-ish vein (which is really, really rare nowadays) and diversity (across gender identity, sexual orientation, age, race, etc.) in its characters still makes it feel very unique and fresh. But I don’t think that’s really what you’re looking for here.
(Also, between this and the GILM nominations I’m convinced that I really need to play Nier: Automata.)
Edit: see the replies.